We detected increased iron deposits in the striatum of post-mortem brain tissue of Huntington’s Disease (HD) patients. High-field T2*-weighted MRI of the striatum showed a different imaging phenotype in HD patients compared to controls, and spatially correlated with the iron distribution obtained from histology. Increased iron was observed in the matrix and in cells morphologically resembling glial cells. These findings bridge the gap between neuropathological and clinical imaging findings and point to iron accumulation as a potential imaging biomarker for disease progression in vivo, possibly reflecting neuroinflammation.
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