Abstract #2784

Investigating Microglial Activation and white matter changes in Huntington Disease Patients

wafaa sweidan¹, navid seraji bozorgzad², edwin george³, fen bao⁴, and rachel darling⁵

¹wayne state university, detroit, MI, United States, ²university of michigan, ann arbor, MI, United States, ³Neurology, wayne state university, detroit, MI, United States, ⁴univeristy health center, detroit, MI, United States, ⁵university health center, detroit, MI, United States

This study will investigate the effects of Huntington disease (HD) progression on white matter microstructure and microglial activation using diffusion magnetic resonance imaging and positron emission tomography in HD patients over the course of 6 months (baseline and 6 month visit). Age-matched healthy controls will be followed up similarly. Baseline differences between HD and healthy controls will likely reflect effect of HD pathology on white matter tracts and assessing longitudinal changes accompanied by disease progression will reflect the temporal and spatial changes.

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