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Abstract #2785

Progressive Supranuclear Palsy versus Parkinson’s disease-related damage using quantitative multimodal MRI

Nadya Pyatigorskaya1,2,3, Lydia Yahia-cherif1,3, Rahul Gaurav1, Claire Ewenczyk4, Cecile Gallea1, Romain Valabregue1, Fatma Gargouri1, Eric Bardinet1, Cyril Poupon5, Marie Vidailhet3,4, and Stephane Lehericy1,2,3

1CENIR, ICM, Paris, France, 2Neuroradiology, APHP, Pitie Salpêtrière, Paris, France, 3Sorbonne Universite, Univ Paris 06, UMR S 1127, CNRS UMR 7225, ICM, Paris, France, 4Clinique des mouvements anormaux, Département des Maladies du Système Nerveux, Hôpital Pitié-Salpêtrière, PARIS, France, 5NeuroSpin, CEA, Gif-Sur-Yvette, France

Our primary objective was to generate a precise in vivo model of neurodegeneration of brainstem nuclei, cerebellum, basal ganglia, basal forebrain, and cortex using multimodal MRI in progressive supranuclear palsy (PSP). Secondary objective was to use multimodal imaging biomarkers to efficiently differentiate PSP from Parkinson disease (PD) patients and healthy control subjects (HC). Multiple factorial analyses of the regional damage allowed to efficiently differentiate PSP from HC and PD, in agreement with previous pathological studies. These results suggest the possibility of direct non-invasive assessment of brain damage at multiple level of the central nervous system in PSP and efficient multimodal multiregional based differential diagnosis between PSP and PD patients

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