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Abstract #2786

Associations Between Dual Task Cost and Striatal Functional Connectivity in Parkinson’s Disease with Mild Cognitive Impairment

Ece Bayram1, Karthik Sreenivasan1, Jason Longhurst1, Sarah Banks2, Zhengshi Yang1, Xiaowei Zhuang1, Dietmar Cordes1, Aaron Ritter1, Jessica Caldwell1, Brent Bluett3, and Virendra Mishra1

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of California, San Diego, La Jolla, CA, United States, 3Stanford University, Stanford, CA, United States

This study investigated striatal functional connectivity correlates of dual-tasking in Parkinson’s disease with and without mild cognitive impairment using resting state fMRI. Increased caudate functional connectivity with frontotemporal, insular and subcortical regions were associated with increased dual task cost in Parkinson’s disease with mild cognitive impairment, whereas correlations were only seen in increased putamen and supplementary motor area functional connectivity and increased dual task cost in PD participants. These results reveal that dual tasking is associated with different striatal functional connectivity patterns in PD participants, with and without, cognitive impairment suggesting compensatory mechanisms in Parkinson’s disease with mild cognitive impairment.

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