Abstract #2790

Microstructural changes of the cortico-striatal pathway in Fabry disease: a diffusion MRI connectometry study

Matteo Battocchio¹, Sirio Cocozza², Simona Schiavi¹, Giuseppe Pontillo², Camilla Russo², Antonio Pisani³, Alessandro Daducci¹, and Arturo Brunetti²

¹Computer Science Department, University of Verona, Verona, Italy, ²Advanced Biomedical Sciences Department, University “Federico II”, Naples, Italy, ³Nephrology Unit, University “Federico II”, Naples, Italy

Aim of this study was to investigate the presence of microstructural alterations along the cortico-striatal pathway of Fabry Disease (FD) patients. Mean Fractional Anisotropy (FA) values of bundles connecting the motor cortex with the striatum were extracted from 15 FD patients and 14 controls.We found a reduction of mean FA values, along bundles of the cortico-striatal pathway in FD patients compared to HC (p=0.04 and p=0.01 for the right and left side, respectively).Our preliminary results confirm the presence of an extrapyramidal involvement in FD patients, showing the presence of microstructural changes affecting the cortico-striatal pathway in this condition.

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