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Abstract #2790

Microstructural changes of the cortico-striatal pathway in Fabry disease: a diffusion MRI connectometry study

Matteo Battocchio1, Sirio Cocozza2, Simona Schiavi1, Giuseppe Pontillo2, Camilla Russo2, Antonio Pisani3, Alessandro Daducci1, and Arturo Brunetti2

1Computer Science Department, University of Verona, Verona, Italy, 2Advanced Biomedical Sciences Department, University “Federico II”, Naples, Italy, 3Nephrology Unit, University “Federico II”, Naples, Italy

Aim of this study was to investigate the presence of microstructural alterations along the cortico-striatal pathway of Fabry Disease (FD) patients. Mean Fractional Anisotropy (FA) values of bundles connecting the motor cortex with the striatum were extracted from 15 FD patients and 14 controls.We found a reduction of mean FA values, along bundles of the cortico-striatal pathway in FD patients compared to HC (p=0.04 and p=0.01 for the right and left side, respectively).Our preliminary results confirm the presence of an extrapyramidal involvement in FD patients, showing the presence of microstructural changes affecting the cortico-striatal pathway in this condition.

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