We report a long-term study of three de novo diagnosed Wilson disease patients with neurological form who repeatedly underwent magnetic resonance imaging and neurological examinations for 2 years after treatment initiation. The quantitative measurement of susceptibility revealed higher values in basal ganglia and thalamus compared to controls which correspond to higher iron accumulation.
Degree of iron load reflected the clinical severity of neurological impairment. Thus, we can suppose that the increase of the brain iron concentration can be a marker of suboptimal response to anti-copper therapy and unfavorable outcome.
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