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Abstract #2795

Chemical exchange saturation transfer imaging depending on several neurodegenerative diseases at 3T

Yuki Matsumoto1, Masafumi Harada1, Yuki Kanazawa1, Takashi Abe1, Maki Otomo1, and Mitsuharu Miyoshi2

1Tokushima University, Tokushima, Japan, 2Global MR Applications and Workflow, GE Healthcare Japan, Tokyo, Japan

In this study, CEST imaging was performed on the substantial nigra, the basal ganglia, and cerebral cortex level to reveal the mechanism each neurodegenerative disease. For this study, patients with Parkinson’s disease, multiple system atrophy, progressive supranuclear palsy, and spinocerebellar degeneration were examined. Region-of-interest analysis was performed in the substantia nigra, red nuclei, lentiform nucleus, and supplementary motor area. As the results, the CEST parameters were significantly different for each of the neurodegenerative diseases. CEST imaging might have the ability to obtain abnormal proteins each of the neurodegenerative diseases.

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