Abstract #2796

Evaluating Countermeasures Against Chemical Warfare Nerve Agents using Diffusion Tensor Imaging

Kevin Lee¹, Matthew Bouchard¹, Sara Bohnert², Steven D Klaassen³, Roland M van den Berg³, Marloes J.A. Joosen³, and Jeff F. Dunn¹

¹Radiology, University of Calgary, Calgary, AB, Canada, ²Defence Research and Development Canada-Suffield Research Centre, Ralston, AB, Canada, ³CBRN Protection, TNO, Rijswijk, Netherlands

Seizures induced by chemical warfare nerve agents cause debilitating neurological damage. It is widely accepted that the main contributor to this neuropathology is excitotoxic damage. Current countermeasures to the damage are effective in preventing mortality, but do not always prevent nerve agent-induced seizures and related neuropathology. We have applied diffusion tensor imaging to study the microstructural changes in the brain to evaluate the efficacy of countermeasures against chemical warfare nerve agents.

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