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Abstract #2798

Quantitative analysis of the wall thickness and enhancement ratio of intracranial aneurysms using high-resolution black-blood imaging at 7T

Zihao Zhang1,2, Qingle Kong1,3, Xinke Liu4, Chengcheng Zhu5, Zhaoyang Fan6, Jing An7, Youxiang Li4, and Yan Zhuo1,2

1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, 3University of Chinese Academy of Sciences, Beijing, China, 4Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Beijing, China, 5Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 6Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 7Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

Three-dimensional turbo-spin-echo (3D-TSE) is increasingly being used in black-blood imaging of intracranial aneurysms. In this study, we optimized the protocol of T1-weighted (T1w) 3D-TSE to reach a high isotropic resolution of 0.40 mm. The inner wall thickness and enhancement ratio were analyzed in sections from ten aneurysms. The segments of aneurysmal walls with a higher wall thickness tend to represent a higher enhancement ratio (Pearson correlation, r = 0.32, p < 0.001). The wall thickness and enhancement ratio should be comprehensively considered to predict the prognosis of intracranial aneurysms.

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