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Abstract #2799

Cardiac and Respiratory induced 3D Brain Tissue Strain as Marker of Physiological Blood Volume Dynamics at 7T MRI.

Jacob Jan Sloots1, Peter R. Luijten1, Geert Jan Biessels2, and Jaco J. M. Zwanenburg1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Neurology, University Medical Center Utrecht, Utrecht, Netherlands

Brain tissue deformation induced by the cardiac and respiration cycles could be a valuable source of information on the physiology of the brains tissue properties. In this work, we assess the tissue deformation by computing the tissue strain from DENSE displacement data sets and unravel cardiac and respiratory contributions by using a linear model. We observed consistent trends in the three strain components due to cardiac and respiration cycles, which agree with blood volume changes. In contrast to tissue displacement, the tissue strain may serve as a reliable novel marker of physiological blood volume dynamics in the brain.

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