Abstract #2805

Longitudinal Study of APT-weighted CEST in the Brain at 7T in Patients with Multiple Sclerosis

Kristin P. O'Grady^1,2, Seth A. Smith^1,2,3, Sanjana Satish², Nirbhay Yadav^4,5, Margaret Spini⁶, Seongjin Choi⁷, and Daniel M. Harrison⁷

¹Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁴The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁶University of Maryland School of Medicine, Baltimore, MD, United States, ⁷Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States

Amide proton transfer weighted chemical exchange saturation transfer (APTw-CEST) MRI has been applied with whole-brain coverage in a longitudinal study in patients with relapsing-remitting, secondary progressive, and primary progressive multiple sclerosis (MS). APTw-CEST is sensitive to amide protons on proteins and peptides and may provide insight into the pathological processes underlying symptoms and disease progression in MS. Our preliminary results show increased APTw-CEST contrast in relapsing-remitting MS patients and decreased contrast in primary progressive MS patients, as well as differences in CEST contrast in lesions for these disease subtypes.

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