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Abstract #2807

Observation of Iron Deposition in Cynomolgus Monkeys with the Parkinson’s Disease using Quantitative Susceptibility Mapping at 7T MRI

Sangwoo Kim1,2, Sukhoon Oh2, Youngjeon Lee3, Chang-Yeop Jeon3, Philyong Kang3, Keunil Kim2, Youngjae Jeon1,2, Jincheol Seo3, Seung Ho Baek3, Yeung Bae Jin3, and Chulhyun Lee1,2

1Bio-Analytical Science, University of Science & Technology, Cheongju, Korea, Republic of, 2Bioimaging Research Team, Korea Basic Science Institute, Cheongju, Korea, Republic of, 3National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Korea, Republic of

The anatomic sensitivity of iron deposition in the Parkinson’s disease (PD) study remains controversial with exception of the substantia nigra (SN). A 14-year-old PD-modeled cynomolgus monkey and an age-matched healthy control were scanned at 7T MRI. The average susceptibility ratio of the caudate nucleus, putamen, thalamus (TH) and SN were increased approximately 21~76 %. We found significantly increased susceptibility values in the SN pars compacta (SNc) and TH. In addition to the high-sensitivity of the SNc in PD, we have also seen that the TH could be a diagnostic biomarker of PD in terms of the movement disorder.

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