Abstract #2809

Optimization of adiabatic pulses for Pulsed Arterial Spin Labeling (pASL) at 7T

Kai Wang¹, Jin Jin^2,3,4, Lirong Yan¹, and Danny Wang¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, United States, ²1 Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ³Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck school of medicine, University of Southern, Los Angeles, CA, United States, ⁴School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Australia

The goal of this work was to optimize and evaluate three types of adiabatic pulses for pulsed ASL (PASL) at 7T including Hyperbolic Secant (HS)[1], WURST[2] and FOCI[3] pulses using theoretical simulation, phantom and in vivo scans. WURST has the lowest loss in simulation and outperforms HS/FOCI in experiments. The optimized WURST pulse with the maximally allowed B1 is preferred to HS and FOCI pulses for adiabatic inversion in 7T PASL.

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