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Abstract #2810

Age-related changes in tissue T1, T2 values of the human brain quantified by 2D PnP-MRF at 7T MRI

Koji Fujimoto1, Martijn A Cloos2, Atsushi Shima3, Dinh Ha Duy Thuy1, Nobukatsu Sawamoto4, Ryosuke Takahashi3, Tadashi Isa1,5, and Tomohisa Okada1

1Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Department of Neuroscience, Graduate School of Medicine, Kyoto University, Kyoto, Japan

To investigate age-related changes in T1 and T2 of brain tissues at 7T, healthy volunteers (N=45, age range 20-81) were scanned using a 1ch-Tx/32ch-Rx coil and a Plug-and-Play MR Fingeprinting (prototype) sequence. Six brain regions (putamen, globus pallidus, caudate head, thalamus, frontal white matter (WM) and frontal gray matter (GM)) were evaluated. Linear and quadratic curve fitting was performed. Significant linear correlation in T2 was found for the putamen and frontal WM and a quadratic correlation was found for the putamen (T2), globus pallidus (T2), thalamus (T1) and frontal WM (T1/T2).

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