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Abstract #2820

Quantitative Assessment of Treatment Efficacy in Acute Ischemia using Perfusion and Diffusion Weighted Imaging at 21.1-T

F. Andrew Bagdasarian1,2, Shannon Helsper1,2, Xuegang Yuan2, Jens T. Rosenberg1, Nastaren Abad1,2, Teng Ma2, and Samuel Colles Grant1,2

1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

This study employs perfusion and diffusion weighted imaging (PDWI) at 21.1 T to identify the pattern of potential recovery of cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) in ischemic stroke with a novel stem cell therapy using dissociated aggregate human mesenchymal stem cells (d-hMSC) in a rodent stroke model. Spanning a week post ischemia, high field MRI was performed with the goal of quantitatively assessing treatment efficacy longitudinally. Results show longer term increase of ADC in the ischemic region and shorter term CBF stabilization in the contralateral region.

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