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Abstract #2819

High Resolution MR Imaging of Amyloid Deposition in 5xFAD Mice Brains at 21.1 T

David C Hike1,2, Tara N Palin3, Scott E Boebinger4, and Samuel Colles Grant1,2

1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States, 3Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 4Biomedical Engineering, Georgia Institute of Technology & Emory University School of Medicine, Atlanta, GA, United States

This study utilizes high resolution 3D images acquired at 21.1 T to display the presence of amyloid plaques, which temporally correlate with the progression of structural connectivity alterations in this transgenic preclinical model. As a function of phenotype, age and gender, high resolution scans were performed on APP/PS1 mouse brains and age-matched wild-type controls. Data indicate that plaques may be visible in mice as young as 4 months without the use of any magnetic contrast agents.

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