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Abstract #2846

Deep Learning for Characterizing Image Sequence Significance in Brain Tissue Segmentation

IVAN CORONADO1, REFAAT GABR1, SUSHMITTA DATTA1, SHEEBA SUJIT1, FRED LUBLIN2, JERRY WOLINSKY3, and PONNADA NARAYANA1

1Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center, Houston, TX, United States, 2Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Neurology, University of Texas Health Science Center, Houston, TX, United States

Deep learning (DL) is an effective way for performing automatic multi-channel (or contrast) semantic segmentation. Here we investigated the accuracy of tissue segmentation as a function of the number and combinations of contrasts to the input of a fully convolutional neural network. The multi-contrast images included FLAIR, pre-contrast T1-, T2-, and proton density-weighted images, acquired on a large cohort of multiple sclerosis patients. Our results show that the number of input channels affects the segmentation accuracy in a tissue-dependent manner and that FLAIR is the major determinant of segmentation accuracy.

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