Abstract #2847

APT-weighted imaging for differentiation between brain tumors of glial origin

Faris Durmo¹, Jimmy Lätt², Anna Rydhög², Johan Bengzon³, Jonas Svensson², Anina Seidemo⁴, Frederik Testud⁵, Benjamin Schmitt⁶, Peter van Zijl^7,8, Linda Knutsson^4,7, and Pia C. Sundgren^1,2,9

¹Clinical Sciences, Department of Radiology, Lund University, Lund, Sweden, ²Center for Medical Imaging and Physiology, Skåne University Hospital, Lund and Malmö, Lund, Sweden, ³Department of Neurosurgery, Lund University, Lund, Sweden, ⁴Department of Medical Radiation Physics, Lund University, Lund, Sweden, ⁵Siemens Healthcare AB, Malmö, Sweden, ⁶Siemens Healthcare Pty. Ltd., Sydney, Australia, ⁷Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁸F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁹Lund university Bioimaging Center, Lund University, Lund, Sweden

Gliomas of different histopathological grades have diametrically different prognosis and need biopsy-verification for diagnosis. Amide Proton Transfer weighted imaging (APTw), a non-invasive CEST MRI technique, was utilised for tumor differentiation of low grade and high grade brain gliomas. Mean lesional APTw-effect was quantified in regions with highest signal in 20 individuals. The information proved to be useful as the findings demonstrated that APTw increased the diagnostic accuracy in the clinical setting which may reduce treatment delay and improve diagnostics. APTw-imaging therefore shows promise as a clinical tool.

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