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Abstract #2847

APT-weighted imaging for differentiation between brain tumors of glial origin

Faris Durmo1, Jimmy Lätt2, Anna Rydhög2, Johan Bengzon3, Jonas Svensson2, Anina Seidemo4, Frederik Testud5, Benjamin Schmitt6, Peter van Zijl7,8, Linda Knutsson4,7, and Pia C. Sundgren1,2,9

1Clinical Sciences, Department of Radiology, Lund University, Lund, Sweden, 2Center for Medical Imaging and Physiology, Skåne University Hospital, Lund and Malmö, Lund, Sweden, 3Department of Neurosurgery, Lund University, Lund, Sweden, 4Department of Medical Radiation Physics, Lund University, Lund, Sweden, 5Siemens Healthcare AB, Malmö, Sweden, 6Siemens Healthcare Pty. Ltd., Sydney, Australia, 7Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 9Lund university Bioimaging Center, Lund University, Lund, Sweden

Gliomas of different histopathological grades have diametrically different prognosis and need biopsy-verification for diagnosis. Amide Proton Transfer weighted imaging (APTw), a non-invasive CEST MRI technique, was utilised for tumor differentiation of low grade and high grade brain gliomas. Mean lesional APTw-effect was quantified in regions with highest signal in 20 individuals. The information proved to be useful as the findings demonstrated that APTw increased the diagnostic accuracy in the clinical setting which may reduce treatment delay and improve diagnostics. APTw-imaging therefore shows promise as a clinical tool.

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