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Abstract #2855

T1 relaxation time in the rotating frame MR imaging of gliomas:efficacy in preoperative grading

Zeyu Zheng1, Jing Zhang1, Yuefa Tan1, Huiyan Li1, Yingjie Mei2, Queenie Chan3, and Yikai Xu1

1Department of Medical Center, Nanfang hospital, Southern Medical University, Guangzhou, China, 2Philips Healthcare, Guangzhou, China, 3Philips Healthcare, Hongkong, China

Accurate glioma grading is crucial for therapeutic strategy and prognosis. T1ρ MRI could probe the interactions between motion-restricted water and macromolecules in tissues. Our study aimed to determine the diagnostic efficiency of T1ρ MRI in glioma grading. Significant differences were found by rT1ρ between low- and high-grade, WHO grade Ⅱ and Ⅲ, WHO grade Ⅱ and Ⅳ gliomas when we placed the ROIs in the solid portion and the peritumoral portion respectively. rT1ρ demonstrated a high diagnostic performance in the solid portion and a moderate diagnostic performance in the peritumoral portion in grading. T1ρ MRI has potential to be a noninvasive quantitative method for preoperatively grading gliomas.

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