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Abstract #2856

The study of relationship between amide proton transfer(APT) imaging and IDH mutation status in patients with high-grade gliomas

Yonglu Chen1,2, Xinfeng Xie1, Yingjie Mei3, Yuelong Yang1, Xiaoling Wu1, Hongjun Liu1, and Biao Huang1

1Department of Radiology, Guangdong General Hospital, Guangdong Academy Of Medical Sicences, Guangzhou, China, 2Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 3Philips Healthcare, Guangzhou, China

We want to investigate the association of amide proton transfer weighted imaging (APTw) with isocitrate dehydrogenase (IDH) wild-type and IDH mutant of high-grade gliomas.All patients underwent MR scan, including APT san to getting the APT values of the whole tumor. The APT value of the IDH wild type group was significantly higher than that of the IDH mutant group. We conclude that APTw can be used to predict the gene type of IDH in high-grade gliomas before surgery.

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