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Abstract #2857

Towards the development of a microstructural model for Brain tumours

Samira Bouyagoub1, Antonella Castellano2, Maira Tariq3, Luisa Altabella2, Andrew Falini2, Eleftheria Panagiotaki3, and Mara Cercignani1

1Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Neuroradiology Unit and CERMAC, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Department of Computer Science, University College London, London, United Kingdom

While several multi-compartment models of diffusion have been developed to describe the healthy neural tissue, most of these models fail in the presence of tumours, because they are unable to capture their heterogeneity. By contrast, models of diffusion able to quantify histologic features of colorectal and prostate tumors in vivo have been proposed. Here we combine the sensitivity of these models to tumour histology and the ability of multi-compartment models of dMRI in the brain to describe the complexity of the neural tissue.

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