Abstract #2860

Classification of IDH and TP53 Mutational Subgroups of High-Grade Astrocytic Gliomas Based on Magnetic Resonance Spectroscopy at 3T

Esin Ozturk-Isik¹, Sevim Cengiz¹, Alpay Ozcan^2,3, Cengiz Yakicier⁴, M. Necmettin Pamir^5,6, Koray Ozduman^5,6, and Alp Dinçer^6,7

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Department of Biomedical Device Technologies, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ³Neuroradiology Research Center, Acıbadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁴Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁵Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁶Neuroradiology Research Center, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁷Department of Radiology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey

The goal of this study is to define MR spectroscopic differences of high-grade astrocytic glioma subgroups classified by IDH and TP53 mutations at 3T. TP-53 mutated (TP53-mut) and TP53 wild-type (TP53-wt) gliomas had similar metabolic profiles. IDH mutation (IDH-mut) was the main factor contributing to the metabolic differences between IDH and TP53 mutational subgroups. IDH-mut/TP53-mut gliomas had lower Glyc (P=0.017), GSH (P=0.009), Glu (P=0.038), and Glx (P=0.002) than IDH-wt/TP53-mut gliomas. Gliomas who were IDH wild-type (IDH-wt) and TP53-mut had the highest Glu, Glyc, GSH, and Glx among all high-grade astrocytic gliomas, which might be indicators of poor overall survival.

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