The aim of the present study is to report the clinical and imaging characteristics of midline gliomas with H3 K27M mutations and to compare them with those gliomas without histone H3 K27M mutation in different age groups. There were 60 midline gliomas with H3 K27M mutation and 62 glioma patients without mutation included in this study. Mutant tumors were more likely diagnosed at an early age and located at infratentorial brain, with less contrast enhancement or edema.
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