Meeting Banner
Abstract #2862

An optimised protocol for dynamic oxygen enhanced imaging of brain tumours

William K Lloyd1, Erjon Agushi1,2, David Coope1,2, Daniel Lewis1,2, Alan Jackson1, and Geoff J M Parker1,3

1University of Manchester, Manchester, United Kingdom, 2Salford Royal NHS Foundation Trust, Manchester Centre for Clinical Neurosciences, Manchester, United Kingdom, 3Bioxydyn Limited, Manchester, United Kingdom

Hypoxia is an important factor in tumour resistance and regression. The use of oxygen as an MR contrast agent is gaining interest but the technique has been hampered by relatively low contrast, noisy data. Here we present an optimised protocol for dynamic oxygen-enhanced MRI (dOE-MRI) of brain tumours. We present data from healthy normal volunteers that demonstrate the method’s capability of producing reliable oxygen-induced signal change and data from glioblastoma (GBM) patients demonstrating tumour sub-division specific changes, showing the potential of this method for mapping tumour hypoxia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here