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Abstract #2877

Feasibility of magnetisation transfer ratio measurements in the proximal lumbar plexus using healthy volunteers at 3T

Marios C Yiannakas1, Torben Schneider2, Masami Yoneyama3, Ferran Prados1,4,5, Olga Ciccarelli1, and Claudia CAM Gandini Wheeler-Kingshott1,6,7

1Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Philips Healthcare, Surrey, United Kingdom, 3Philips Healthcare, Tokyo, Japan, 4Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 5Universitat Oberta de Catalunya, Barcelona, Spain, 6Brain MRI 3T Research Centre, IRCCS Mondino Foundation, Pavia, Italy, 7Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

Magnetic resonance neurography (MRN) has become a widely used non-invasive tool for assessing the lumbar plexus with application to inflammatory, neoplastic, metabolic and traumatic pathologic conditions. Given that the main pathological process involved in the majority of these neurological conditions results in the alteration of myelin content, this pilot study proposes and demonstrates in healthy controls the feasibility of using MRN to facilitate reliable measurements of magnetisation transfer ratio, a biophysically meaningful MR biomarker, which has been shown to be directly influenced by the amount of myelin in neural tissue.

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