Abstract #2878

Simultaneous Voxel Based Analysis of Brain and Spinal Cord: Application to Spinal Cord Injury Patients

Michela Azzarito¹, Claudia Blaiotta2², John Ashburner², Yaël Balbastre², Sreenath Pruthvi Kyathanahally¹, Martina Callaghan², Maryam Seif¹, and Patrick Freund^1,2,3,4

¹Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zürich, Switzerland, ²Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, UK, London, United Kingdom, ³Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Leipzig, Germany, ⁴Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, UK, London, United Kingdom

Assessing the sequelae of a focal CNS injury across the entire neuroaxis holds great potential to better understand the temporal and spatial distributed pathophysiological changes. Currently, voxel-based analysis is either performed at the level of the spinal cord or brain. As a result, most imaging studies fail to implement and analyse the interactions between remote areas across the CNS. In this study, a new probabilistic-atlas including brain and cervical spinal cord (SC) was used for the simultaneous, fully automated and multi-parametric analysis in SPM framework. This approach was validated by assessing trauma-induced changes in SCI patients and compared with findings from analytical tools assessing the brain and cord separately.

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