Meeting Banner
Abstract #2878

Simultaneous Voxel Based Analysis of Brain and Spinal Cord: Application to Spinal Cord Injury Patients

Michela Azzarito1, Claudia Blaiotta22, John Ashburner2, Yaël Balbastre2, Sreenath Pruthvi Kyathanahally1, Martina Callaghan2, Maryam Seif1, and Patrick Freund1,2,3,4

1Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zürich, Switzerland, 2Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, UK, London, United Kingdom, 3Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Leipzig, Germany, 4Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, UK, London, United Kingdom

Assessing the sequelae of a focal CNS injury across the entire neuroaxis holds great potential to better understand the temporal and spatial distributed pathophysiological changes. Currently, voxel-based analysis is either performed at the level of the spinal cord or brain. As a result, most imaging studies fail to implement and analyse the interactions between remote areas across the CNS. In this study, a new probabilistic-atlas including brain and cervical spinal cord (SC) was used for the simultaneous, fully automated and multi-parametric analysis in SPM framework. This approach was validated by assessing trauma-induced changes in SCI patients and compared with findings from analytical tools assessing the brain and cord separately.

This abstract and the presentation materials are available to members only; a login is required.

Join Here