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Abstract #2879

Investigating microstructural correlates of neuropathic pain in spinal cord injury patients using source-based morphometry

Sreenath P Kyathanahally1, Michela Azzarito1, and Patrick Freund1

1Spinal cord injury center Balgrist, University of Zurich, Zurich, Switzerland

Spinal cord injury (SCI) triggers a cascade of neurodegenerative and compensatory changes across the neuroaxis. The majority of SCI patients develop neuropathic pain (NP) as a secondary complication. In this study, we applied source-based-morphometry to investigate remote microstructural changes sensitive to myelin and iron deposition in brain areas associated with pain processing and explored the associations of these microstructural changes with pain intensity.

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