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Abstract #2885

Investigation of DTI parameters in the corticospinal tract: from cervical cord to motor cortex

Rebecca Sara Samson1, Jon Stutters1, Muhammad Ali Akbar2, Julien Cohen-Adad3,4, Armin Curt5, Michael Fehlings2,6, Patrick Freund5,7,8, Maryam Seif5, and Claudia Angela Gandini Wheeler-Kingshott1,9,10

1Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 2Institute of Medical Science, University of Toronto, Toronto, ON, Canada, 3NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 4Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, 5Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, 6Krembil Research Institute (Krembil), University Health Network, Toronto, ON, Canada, 7Department of Neurophysics, Wellcome Trust Centre for Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 8Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 9Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 10Brain MRI 3T Centre, IRCCS Mondino Foundation, Pavia, Italy

We have explored diffusion tensor imaging (DTI) metrics along the corticospinal tract (CST) from the cervical cord to the motor cortex, measured using separate whole brain and cervical cord DTI protocols in healthy subjects at two different sites. We have also explored sensitivity to disease in patients with cervical spondylotic myelopathy (CSM), and spinal cord injury (SCI). Several studies have looked either at brain or cervical cord separately, which makes it difficult to learn about possible interactions between brain and cord. Here, we combine brain and cord measurements and examine how the CST is affected in CSM and SCI.

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