Abstract #2885

Investigation of DTI parameters in the corticospinal tract: from cervical cord to motor cortex

Rebecca Sara Samson¹, Jon Stutters¹, Muhammad Ali Akbar², Julien Cohen-Adad^3,4, Armin Curt⁵, Michael Fehlings^2,6, Patrick Freund^5,7,8, Maryam Seif⁵, and Claudia Angela Gandini Wheeler-Kingshott^1,9,10

¹Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ²Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ³NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ⁴Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, ⁵Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, ⁶Krembil Research Institute (Krembil), University Health Network, Toronto, ON, Canada, ⁷Department of Neurophysics, Wellcome Trust Centre for Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁸Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁹Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ¹⁰Brain MRI 3T Centre, IRCCS Mondino Foundation, Pavia, Italy

We have explored diffusion tensor imaging (DTI) metrics along the corticospinal tract (CST) from the cervical cord to the motor cortex, measured using separate whole brain and cervical cord DTI protocols in healthy subjects at two different sites. We have also explored sensitivity to disease in patients with cervical spondylotic myelopathy (CSM), and spinal cord injury (SCI). Several studies have looked either at brain or cervical cord separately, which makes it difficult to learn about possible interactions between brain and cord. Here, we combine brain and cord measurements and examine how the CST is affected in CSM and SCI.

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