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Abstract #2884

Quantitative MRI investigation above a cervical myelopathy in traumatic and non-traumatic spinal cord injury

Maryam Seif1,2, Gergely David1, Eveline Huber 1, Patrick Grabher1, Markus Hupp1, Armin Curt1, and Patrick Freund1,2,3,4

1Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 4Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

Traumatic Cervical Spinal Cord Injury (tSCI) and non-traumatic Cervical Spondylotic Myelopathy (CSM) present a focal damage to the cervical cord with different time profile. Myelin and axonal loss occurs in SCI and CSM; however, little is known how these neurodegenerative changes are comparable in both groups. Therefore, we applied T2*-weighted and DTI MRI at the cervical cord to compare macro/microstructural changes in CSM and tSCI. While the macrostructural changes were similar in both groups, DTI detected more microstructural changes in SCI. Time-dependent compensatory mechanism in CSM might account for less neurodegeneration and better clinical function compared to tSCI.

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