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Abstract #2902

Assessment of early therapeutic response in glioblastoma using advanced DWI-MRI and histogram analysis

Shah Islam1, Melanie Morrison1, Anastasia Gontsarova2, Matthew Orton3, Matt Grech-Sollars4, Eric Aboagye4, and Adam Waldman5

1Brain Sciences, Imperial College London, London, United Kingdom, 2Neuroradiology, Imperial College Healthcare NHS Trust, London, United Kingdom, 3CRUK and EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, United Kingdom, 4Surgery and Cancer, Imperial College London, London, United Kingdom, 5Clinical Brain Sciences, University of Edinburgh, Edinurgh, United Kingdom

Glioblastoma is one of the most aggressive brain tumours, with a life expectancy of 12-15 months. Structural MRI lacks sensitivity for detecting early therapeutic response. DWI is sensitive to changes in cellular density and provides a marker of cell kill. There is little published data on which of the diffusion components detectable in diseased brain tissue in vivo is most sensitive to this. Voxel by voxel pre- and post-treatment analysis in ‘functional diffusion map’ studies are confounded by change in tumour size. We assess the utility of a spatially-independent histogram approach to detect early treatment response using advanced DWI models.

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