Abstract #2908

Diagnostic accuracy of serial 99mTc MDM (bis-Methionine-DTPA) SPECT imaging in differentiation of glioma recurrence from radiation Necrosis: A comparative study with Dynamic Susceptibility Contrast-Enhanced (DSCE)-MRI and Magnetic Resonance Spectroscopy (MRS)

Nisha Rani¹, Prof Baljinder Singh¹, Dr Naredra Kumar², Dr Paramjeet Singh³, Dr Anil Kumar Mishra⁴, and Dr Puja Hazari⁴

¹Nuclear medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ²Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ³Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁴Division of Cyclotron and Radiopharmaceutical Sciences, INMAS DRDO, Delhi, India

The use of complimentary imaging modalities in the glioma management of individual patients can provide additional information for further treatment strategy. In view of the limitations of anatomical imaging, cumbersome radio labeling procedures of PET tracers with amino-acids, in the present study, we have performed multimodality imaging using 99mTc-methionine SPECT (as cost effective substitute for expensive amino acid PET imaging), perfusion MRI and MRS for the the differentiation of radiation necrosis from recurrent/residual glioma by the means of serial imaging.

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