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Abstract #2908

Diagnostic accuracy of serial 99mTc MDM (bis-Methionine-DTPA) SPECT imaging in differentiation of glioma recurrence from radiation Necrosis: A comparative study with Dynamic Susceptibility Contrast-Enhanced (DSCE)-MRI and  Magnetic Resonance Spectroscopy (MRS)

Nisha Rani1, Prof Baljinder Singh1, Dr Naredra Kumar2, Dr Paramjeet Singh3, Dr Anil Kumar Mishra4, and Dr Puja Hazari4

1Nuclear medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 3Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 4Division of Cyclotron and Radiopharmaceutical Sciences, INMAS DRDO, Delhi, India

The use of complimentary imaging modalities in the glioma management of individual patients can provide additional information for further treatment strategy. In view of the limitations of anatomical imaging, cumbersome radio labeling procedures of PET tracers with amino-acids, in the present study, we have performed multimodality imaging using 99mTc-methionine SPECT (as cost effective substitute for expensive amino acid PET imaging), perfusion MRI and MRS for the the differentiation of radiation necrosis from recurrent/residual glioma by the means of serial imaging.

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