Abstract #2909

Parameters From Dynamic Contrast-Enhanced Magnetic Resonance Imaging Are Biomarkers Predicting Response after Radiotherapy to Brain Metastases

Peng Wang¹, Zhuo Shi¹, Lizhi Xie², Yuqing Shang³, XinMing Zhao¹, and Han Ou-Yang¹

¹Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²GE Healthcare, China, Beijing, China, ³Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, United States

Dynamic contrast-enhanced (DCE) MRI provides additional information regarding blood-brain barrier integrity, and K^trans is directly proportional to the level of permeability of the blood-brain barrier. In our study, we demonstrated that SRS of cerebral metastasis was associated with a decrease of K^trans values in the early post-treatment period. DCE-MRI derived parameters can be a promising imaging biomarker of tumor aggressiveness.

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