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Abstract #2909

Parameters From Dynamic Contrast-Enhanced Magnetic Resonance Imaging Are Biomarkers Predicting Response after Radiotherapy to Brain Metastases

Peng Wang1, Zhuo Shi1, Lizhi Xie2, Yuqing Shang3, XinMing Zhao1, and Han Ou-Yang1

1Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2GE Healthcare, China, Beijing, China, 3Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, United States

Dynamic contrast-enhanced (DCE) MRI provides additional information regarding blood-brain barrier integrity, and Ktrans is directly proportional to the level of permeability of the blood-brain barrier. In our study, we demonstrated that SRS of cerebral metastasis was associated with a decrease of Ktrans values in the early post-treatment period. DCE-MRI derived parameters can be a promising imaging biomarker of tumor aggressiveness.

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