Abstract #2922

Reduced Cerebral Blood Flow in Aging Adults with Down Syndrome: An Arterial Spin Labeling Study

Scott William Thalman^1,2, Ai-Ling Lin^1,3,4, Alex Helman⁵, Stacey L Brothers⁶, Kathryn O'Connor⁴, Nathan Johnson⁷, Anders Andersen^8,9, Katie McCarty⁴, Mary Roberta Davis⁴, Gregory Jicha^4,10, Allison Caban-Holt^4,11, William Robertson^10,12, Donita Lightner¹⁰, David Powell^9,13, Elizabeth Head^3,4, and Frederick Schmitt^10,11,14

¹F. Joseph Halcomb III, MD Department of Biomedical Engineering, University of Kentucky, Lexington, KY, United States, ²MD/PhD Program, University of Kentucky, Lexington, KY, United States, ³Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY, United States, ⁴Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States, ⁵Molecular & Cellular Biochemistry, University of Kentucky, Lexington, KY, United States, ⁶Pharmaceutical Sciences, University of Kentucky, Lexington, KY, United States, ⁷Health Sciences - Rehabilitation Science, University of Kentucky, Lexington, KY, United States, ⁸MAgnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, United States, ⁹Neuroscience, University of Kentucky, Lexington, KY, United States, ¹⁰Neurology, University of Kentucky, Lexington, KY, United States, ¹¹Behavioral Science, University of Kentucky, Lexington, KY, United States, ¹²Pediatric Neurology, University of Kentucky, Lexington, KY, United States, ¹³Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, United States, ¹⁴Psychiatry, University of Kentucky, Lexington, KY, United States

Adults with Down syndrome (DS) represent an important model of Alzheimer disease in the absence of cerebrovascular disease (CVD) risk factors like atheroma and hypertension. In this study we used pulsed arterial spin labeling (PASL) to measure cerebral blood flow (CBF) in aging adults with DS and age-matched controls. In adults with DS there is a 31% reduction in CBF after the age of 54 (<54= 46.7mL/100g/min, >54= 32.3mL/100g/min, p=0.011). Despite their CVD protective phenotype, adults with DS do develop vascular dysfunction, however the onset is concurrent with dementia rather than preceding it.

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