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Abstract #2925

The Acute Effects of Cigarette Smoking on Brain Oxygenation and Perfusion Measured by Multi-Parametric Quantitative BOLD and Arterial Spin Labeling MRI: Preliminary Results

Sebastian Thomas1,2, Simon Hubertus1,2, Ioanna Skampardoni1, Natalie Hartig2, Sabine Vollstaedt-Klein*2, and Lothar R. Schad*1

1Computer Assisted Clincial Medicine, Heidelberg University, Mannheim, Germany, 2Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany

The effects of smoking on human brain hemodynamics have been investigated for many years, but no real consensus was found. In this study, the acute effects of cigarette smoking on the cerebral blood flow, oxygen extraction fraction and cerebral metabolic rate of oxygen are measured with a multi-parametric quantitative BOLD approach. So far, no significant difference between pre- and post-smoking was found. However, the number of subjects will be increased from 5 to 20 in the course of this ongoing study.

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