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Abstract #2926

Is cerebral blood flow affected by preventable neurovascular risk factors and physical fitness level?

Lisa A van der Kleij1, Nina L. Højland Reislev2, Christian S. Eriksen3,4, Hartwig R. Siebner2, Carl-Johan Boraxbekk2, Erik L. Mortensen4,5, Jeroen Hendrikse1, Michael Kjaer3,4, Esben T Petersen2, and Ellen Garde2,4,5

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 3Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg and Frederiksberg University Hospitals, Copenhagen, Denmark, 4Centre for Healthy Aging, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark, 5Department of Public Health, Copenhagen University, Copenhagen, Denmark

The health-related effects of aging (biological age) are highly variable across individuals with a similar chronological age. In this study we investigate the relationship between neurovascular health, physical fitness and mean gray matter cerebral blood flow (CBF) in a cohort of 300 home-dwelling volunteers between 62 and 70 years old. In these population-based elderly participants we found that preventable risk factors for neurovascular disease are associated with cerebral blood flow. A high mean arterial pressure, high cholesterol and low creatinine were associated with a decreased gray matter perfusion, whereas physical fitness was not.

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