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Abstract #2929

Measuring cerebrovascular reactivity without gas challenge: a real-time phase-contrast MRI approach

Jingran Zhu1, Dengrong Jiang1, Michael Schär1, Dirk Voit2, Jens Frahm2, Paul Bottomley1, Hanzhang Lu1, and Peiying Liu1

1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Biomedizinische NMR, MPI fuer Biophysikalische Chemie, Goettingen, Germany

Cerebrovascular reactivity (CVR) is typically measured from changes in cerebral perfusion responsive to a hypercapnic gas challenge. Recent attempts to measure CVR using resting-state BOLD fMRI without gas challenge have utilized spontaneous fluctuations in breathing patterns. Since BOLD signal is an indirect measure of cerebral perfusion, a technique that enables cerebral blood flow (CBF)-based CVR under free-breathing conditions is highly desirable. Here, we used a real-time (17 fr/s) PC MRI to measure CBF-based CVR in the resting-state. We evaluated the feasibility of this new approach, and compared it with real-time PC MRI with gas-inhalation, and regular PC MRI with gas-inhalation.

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