Cerebral amyloid angiopathy is a small vessel disease characterised by imaging signatures including cerebral microbleeds and cortical superficial siderosis. We show here that non-local phase effects affecting Susceptibility Weighted Imaging (SWI) cause broadening and/or duplication of microbleeds, as well as deformation of superficial siderosis. Furthermore, susceptibility maps and “true SWI”, where local susceptibility values are used, facilitate more accurate microbleed size estimation, reduce the risk of microbleed miscount and provide better delineation of superficial siderosis. Therefore, susceptibility maps and true SWI are likely to be more accurate than SWI in identifying and grading these haemorrhagic markers, with potential clinical relevance.
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