Abstract #2934

Cerebral Metabolic Rate of Oxygen (CMRO2) during transition from wakefulness to sleep measured by high temporal resolution OxFlow MRI with concurrent EEG recording

Alessandra Caporale¹, Hyunyeol Lee¹, Hengyi Rao², Hui Lei², John A Detre³, Michael C Langham¹, Pei-Hsin Wu¹, and Felix W Wehrli¹

¹Radiology, Laboratory for Structural, Physiologic and Functional Imaging, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States, ²Center for Functional Neuroimaging & Division of Sleep and Chronobiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States, ³Neurology, Perelman School of Medicine, University of Pennsylvania Health System, Philadelphia, PA, United States

Reduced synaptic transmissions during states of reduced consciousness cause a slowdown in the cerebral metabolic rate of oxygen (CMRO₂) and glucose utilization. Prior methods based on PET and tracer kinetics involving repeated blood sampling are not practical in a clinical setting. Here we used whole-brain MR oximetry at 3-second temporal resolution with simultaneous EEG recording to evaluate the feasibility of in-scanner monitoring of brain oxygen metabolism during wakefulness and sleep. The results in three subjects show reduction in CMRO₂ up to 15% following onset of sleep paralleling increased delta wave EEG activity and reduction in heart rate.

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