Abstract #2971

A Single-Compartment Perfusion Phantom for ASL-MRI

Marianna Gabrielyan¹, Christopher Higgins², Paulo E. Arratia², John A. Detre^1,3, and M. Dylan Tisdall³

¹Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ²Mechanical Engineering and Applied Mechanics, Chemical and Biomolecular Engineering, University of Pennsilvania, Philadelphia, PA, United States, ³Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

ASL MRI uses arterial blood water as a diffusible tracer for noninvasive quantification of CBF in physiological units. To produce reliable results across platforms and across subjects, ASL MRI protocols need to be calibrated against a sample with known properties, but it is challenging to simulate tissue perfusion in a mechanical phantom. In this study we present a 3D printed ASL perfusion phantom based on a fluid dynamics model.

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