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Abstract #2971

A Single-Compartment Perfusion Phantom for ASL-MRI

Marianna Gabrielyan1, Christopher Higgins2, Paulo E. Arratia2, John A. Detre1,3, and M. Dylan Tisdall3

1Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 2Mechanical Engineering and Applied Mechanics, Chemical and Biomolecular Engineering, University of Pennsilvania, Philadelphia, PA, United States, 3Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

ASL MRI uses arterial blood water as a diffusible tracer for noninvasive quantification of CBF in physiological units. To produce reliable results across platforms and across subjects, ASL MRI protocols need to be calibrated against a sample with known properties, but it is challenging to simulate tissue perfusion in a mechanical phantom. In this study we present a 3D printed ASL perfusion phantom based on a fluid dynamics model.

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