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Abstract #3011

White Matter Microstructural Change Following Traumatic Brain Injury Assessed by Biophysical Modeling using Simultaneous Multi-Slice Multi-Shell Diffusion MRI

Ping-Hong Yeh1, Chihwa Song1, Cheng Guan Koay1, Wei Liu1, Grant Bonavia1, John Ollinger1, and Gerard Riedy1

1National Intrepid Center of Excellence (NICoE), Walter Reed National Military Medical Center, Bethesda, MD, United States

Mild traumatic brain injury (mTBI) is difficult to diagnose and characterize. In this study, we applied simultaneous multi-slice multi-shell diffusion MRI to assess white matter microstructural changes in chronic military mTBI. Preliminary results showed parameters derived from diffusion MRI biophysical modeling are superior to the parameters derived from diffusion tensor imaging in differentiating tissues with distinct structural and architectural features, and thus has increased ability to identify microstructural changes in mTBI.

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