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Abstract #3012

Mild TBI Patients Continue to Recover from Perfusion Deficits Months after Initial Injury Evaluated with Dynamic Susceptibility Contrast Imaging

Wei Liu1,2, Ping-Hong Yeh1, Chihwa Song1, Dominic E Nathan1,2, Rael Lange1,3, Louis M French1,3, Tracey A Brickell1,3, Sara M Lippa1,3, Grant H Bonavia1, John M Ollinger1, and Gerard Riedy1

1National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, United States, 2The NorthTide Group LLC, Sterling, VA, United States, 3Defense and Veterans Brain Injury Center, Walter Reed National Military Medical Center, Bethesda, MD, United States

Dynamic susceptibility imaging was performed on 7 mild TBI (mTBI) patients and 16 aged matched controls. Patients were scanned at three intervals: 143 ± 56 days, 277 ± 72 days and 918 ± 353 days after injury. The rCBF of mTBI patients in the cerebellum and cuneus was lower compared to the controls at the fist scan, but continued to increase over time. As a result, mTBI patients demonstrated similar rCBF of the control subjects at the last scan. This finding suggests mTBI patients continue to recover from perfusion deficits months after their initial injury.

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