Abstract #3013

Perfusion and brain volume loss after traumatic brain injury

Lisa A. van der Kleij¹, Jill B. De Vis², Matthew C. Restivo³, Lisa C. Turtzo², Jeroen Hendrikse¹, and Lawrence L. Latour²

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ³Division of Intramural Research, National Heart Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States

How can we identify traumatic brain injury (TBI) patients at risk for long-term brain injury? In this longitudinal study, 57 patients with a relatively good clinical status on admission underwent MRI within 48 hours and at 90 days after injury. Brain volume changes were markedly larger in patients with subarachnoid hemorrhage (-3.2%) compared to patients without subarachnoid hemorrhage (-0.4%; P <0.001). Perfusion was moderately correlated with brain volume change at 90 days (ρ = 0.39; P = 0.003). This demonstrates the utility of imaging markers on acute MRI, especially subarachnoid blood, to identify patients at risk for long-term brain injury.

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