Abstract #3015

Elevated serum inflammation-related cytokines predict longitudinal changes of white matter integrity in mild traumatic brain injury

Zhuonan Wang¹, Lijun Bai², Yingxiang Sun¹, Bo Yin³, Guanghui Bai⁴, Feng Zhu⁵, Kevin K.W Wang⁶, and Ming Zhang¹

¹Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xian, China, ²The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China, ³Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, ⁴Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, ⁵Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xian, China, ⁶Psychiatry & Neuroscience, Center for Neuroproteomics and Biomarkers Research, University of Florida, Gainesville, FL, United States

Mild traumatic brain injury (mTBI) is the most prevalent neurological insult and approximately 30% of patients have persistently poor clinical outcomes after injury. Evidence indicated both the inflammatory process and white matter (WM) tracts integrity play the crucial roles in clinical outcomes after mTBI. Our study combined inflammation-related cytokines and WM structure changes to examine the dynamic association between white matter integrity and cytokines in mTBI with longitudinal observations. The results had the potential clinical significance and suggested an early intervention on the inflammatory cytokines in order to decrease the structural integrity loss in the WM tracts.

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