Abstract #3016

Longitudinal White-Matter Abnormalities in Sports-Related Concussion: A Study of Diffusion Magnetic Resonance Imaging from the NCAA-DoD CARE Consortium

Yu-Chien Wu¹, Sourajit M Mustafi¹, Jaroslaw Harezlak², Nahla M Elsaid¹, Zikai Lin³, Larry M Riggen⁴, Kevin Koch⁵, Andrew Nencka⁵, Timothy Meier⁵, Yang Wang⁵, Christopher Giza⁶, John DiFiori⁶, Kevin Guskiewicz⁷, Jason Mihalik⁷, Stephen LaConte⁸, Stefan Duma⁸, Steven Broglio⁹, Michael McCrea⁵, Andrew Saykin¹, and Thomas McAllister³

¹Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Indiana University School of Public Health, Bloomington, IN, United States, ³Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States, ⁴Biostatistics, Indiana University School of Medicine, Indianapoilis, IN, United States, ⁵Medical College of Wisconsin, Milwaukee, WI, United States, ⁶University of California Los Angeles, Los Angeles, CA, United States, ⁷University of North Carolina, Chapel Hill, NC, United States, ⁸Virginia Tech University, Roanoke, VA, United States, ⁹University of Michigan, Ann Arbor, MI, United States

In this study, we investigated the longitudinal recovery trajectories of white-matter microstructures in collegiate athletes who sustained sports-related concussion (SRC). We use diffusion tensor imaging (DTI) to detect white-matter alterations in collegiate athletes longitudinally at four timepoints: 24-48 hours postinjury, the point at which asymptomatic (cleared for return-to-play), seven days following return-to-play, and six months postinjury. We are interested in the extent of white-matter abnormalities over time and whether the white-matter changes persist beyond the point when athletes are considered clinical recovered (i.e., with normal clinical assessments).

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