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Abstract #3016

Longitudinal White-Matter Abnormalities in Sports-Related Concussion: A Study of Diffusion Magnetic Resonance Imaging from the NCAA-DoD CARE Consortium

Yu-Chien Wu1, Sourajit M Mustafi1, Jaroslaw Harezlak2, Nahla M Elsaid1, Zikai Lin3, Larry M Riggen4, Kevin Koch5, Andrew Nencka5, Timothy Meier5, Yang Wang5, Christopher Giza6, John DiFiori6, Kevin Guskiewicz7, Jason Mihalik7, Stephen LaConte8, Stefan Duma8, Steven Broglio9, Michael McCrea5, Andrew Saykin1, and Thomas McAllister3

1Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Indiana University School of Public Health, Bloomington, IN, United States, 3Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States, 4Biostatistics, Indiana University School of Medicine, Indianapoilis, IN, United States, 5Medical College of Wisconsin, Milwaukee, WI, United States, 6University of California Los Angeles, Los Angeles, CA, United States, 7University of North Carolina, Chapel Hill, NC, United States, 8Virginia Tech University, Roanoke, VA, United States, 9University of Michigan, Ann Arbor, MI, United States

In this study, we investigated the longitudinal recovery trajectories of white-matter microstructures in collegiate athletes who sustained sports-related concussion (SRC). We use diffusion tensor imaging (DTI) to detect white-matter alterations in collegiate athletes longitudinally at four timepoints: 24-48 hours postinjury, the point at which asymptomatic (cleared for return-to-play), seven days following return-to-play, and six months postinjury. We are interested in the extent of white-matter abnormalities over time and whether the white-matter changes persist beyond the point when athletes are considered clinical recovered (i.e., with normal clinical assessments).

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