Abstract #3017

Effects of Tract Length in White Matter Alterations After Sports-Related Concussion: A Diffusion MRI Study from the NCAA-DoD CARE Consortium

Yu-Chien Wu¹, Sourajit M Mustafi¹, Jaroslaw Harezlak², Nahla M Elsaid¹, Larry M Riggen³, Kevin Koch⁴, Andrew Nencka⁴, Timothy Meier⁴, Yang Wang⁴, Christopher Giza⁵, John DiFiori⁵, Kevin Guskiewicz⁶, Jason Mihalik⁶, Stephen LaConte⁷, Stefan Duma⁷, Steven Broglio⁸, Michael McCrea⁴, Andrew Saykin¹, and Thomas McAllister⁹

¹Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Indiana University School of Public Health, Bloomington, IN, United States, ³Biostatistics, Indiana University School of Medicine, Indianapoilis, IN, United States, ⁴Medical College of Wisconsin, Milwaukee, WI, United States, ⁵University of California Los Angeles, Los Angeles, CA, United States, ⁶University of North Carolina, Chapel Hill, NC, United States, ⁷Virginia Tech University, Roanoke, VA, United States, ⁸University of Michigan, Ann Arbor, MI, United States, ⁹Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States

In the present study, we performed streamline tractography to characterize effects of tract length on white-matter microstructural alterations after sports-related concussion. Streamline length and counts were studied in affected white-matter fiber tracts that were found to have impaired white-matter integrity at some points along the tracts using voxel-based analyses. The results suggested that long fibers in the brains of collegiate athletes who sustained sports-related concussion are more vulnerable to this mild traumatic brain injury.

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