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Abstract #3022

Comparison of 2D BLADE and Spin-Echo Echo­-Planar Diffusion-Weighted Brain MRI at 3 Tesla: Preliminary Experience in Children

Aaron S McAllister1, Lacey J. Lubeley1, Bhavani Selvaraj1, Ning Jin2, Kun Zhou3, Mark Smith1, Ramkumar Krishnamurthy1, and Houchun Harry Hu1

1Radiology, Nationwide Children's Hospital, Columbus, OH, United States, 2Siemens Medical Solutions, Cleveland, OH, United States, 3Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

We describe our preliminary experience using a GRASE (gradient-echo and spin-echo hybrid) based DWI-BLADE pulse sequence in 53 pediatric patients at 3T. On a 4-point scale for rating diagnostic image quality and impact of artifacts, 1 (best) – 4 (worst), a neuroradiologist scored conventional spin-echo EPI DWI 2.4±0.7 whilst BLADE scored 1.1±0.3 (p<0.01). Overall, DWI-BLADE exhibited less geometric distortion at the periphery of the brain, and reduced signal pile-ups at areas of high susceptibility. The pulse sequence is particularly useful in patients with shunts and dental fixtures and is a viable alternative to conventional spin-echo EPI DWI.

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