We describe our preliminary experience using a GRASE (gradient-echo and spin-echo hybrid) based DWI-BLADE pulse sequence in 53 pediatric patients at 3T. On a 4-point scale for rating diagnostic image quality and impact of artifacts, 1 (best) – 4 (worst), a neuroradiologist scored conventional spin-echo EPI DWI 2.4±0.7 whilst BLADE scored 1.1±0.3 (p<0.01). Overall, DWI-BLADE exhibited less geometric distortion at the periphery of the brain, and reduced signal pile-ups at areas of high susceptibility. The pulse sequence is particularly useful in patients with shunts and dental fixtures and is a viable alternative to conventional spin-echo EPI DWI.
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