Abstract #3029

What’s shape got to do with it? Exploring subcortical shape and volume alterations in youth with congenital heart disease

Kimberly Fontes^1,2, Charles V. Rohlicek³, Christine Saint-Martin⁴, Guillaume Gilbert⁵, Kaitlyn Easson^1,2, Annette Majnemer⁶, Mallar M. Chakravarty^1,7, and Marie Brossard-Racine^1,2,6

¹Advances in Brain and Child Development Research Laboratory, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada, ³Department of Cardiology, Montreal Children’s Hospital, McGill University Health Centre, Montreal, QC, Canada, ⁴Department of Medical Imaging, Montreal Children’s Hospital, McGill University Health Centre, Montreal, QC, Canada, ⁵MR Clinical Science, Philips Healthcare, Markham, ON, Canada, ⁶Department of Pediatrics, Montreal Children’s Hospital, McGill University Health Centre, Montreal, QC, Canada, ⁷Computational Brain Anatomy Laboratory, Cerebral Imaging Centre – Douglas Mental Health University Institute, Verdun, QC, Canada

Congenital heart disease (CHD) is a leading cause of long-lasting neurodevelopmental impairment. Evaluating subtle neuroanatomical variation using magnetic resonance imaging data has been shown to be sensitive for capturing morphometric signatures related to neurodevelopmental disorders. In this study, we found morphometric differences in subcortical structures of youth with CHD even in the absence of volumetric differences. While we did not find any significant morphometric differences between groups for the striatum, we did find smaller surface area and inward bilateral inward displacement across the lateral surfaces of the globus pallidus and the thalamus in the CHD group compared to controls.

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