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Abstract #3030

Characterization of Diffusion Anisotropy Alterations Associated with Dilated Virchow Robin Spaces in Simple Febrile Seizure Children between 12 and 48 Months

Mustafa Salimeen Abdelkareem1, Xianjun Li1, Miaomiao Wang1, Congcong Liu1, Habib Tafawa1, Anuja Pradhan1, Martha Singh1, Xiaocheng Wei2, Guanyu Yang3, and Jian Yang1,4

1Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, 2MR Research China, GE Healthcare, Beijing, China, Xi’an, China, 3Xi'an AccuRad Network and Technology Co. Ltd., Xi'an, China, Xi’an, China, 4Department of Biomedical Engineering, School of Life Science and Technology, Xi’an, China

Dilated Virchow Robin spaces (dVRs) are common in febrile seizure (FS) patients. However, little is known about how dVRs affect the white matter structure in developing brains. This study aimed to characterize the anisotropy alterations in white matter associated with dVRs in simple FS children by using fractional anisotropy (FA). Through inter-group comparisons, FA was larger in simple FS with dVRs children than that in FS without dVRs and control groups. Significant positive correlations between FA and VRs count, seizure duration were found. These results suggest that dVRs can affect the structure of white matter by increasing FA values.

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