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Abstract #3046

Hyperactivity of hippocampus-amygdala network during cue-reward association learning of APP/PS1 Alzheimer’s disease model mice detected by 14T-fMRI

Keisuke Sakurai1, Teppei Shintani1, and Tatsuhiro Hisatsune1

1Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

Dys-regulation of neural network is a biomarker for neurodegenerative disease, such as Alzheimer’s disease. We prepared numbers of 12-month-old APP/PS1 Alzheimer’s disease (AD) model mice and obtained series of BOLD fMRI (SE-EPI) data during cue-reward association learning. We pointed out hyperactivity of amygdala as well as hippocampus in the AD mice, which may involve in a cause for alteration of behavior phenotype in the AD.

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