Dys-regulation of neural network is a biomarker for neurodegenerative disease, such as Alzheimer’s disease. We prepared numbers of 12-month-old APP/PS1 Alzheimer’s disease (AD) model mice and obtained series of BOLD fMRI (SE-EPI) data during cue-reward association learning. We pointed out hyperactivity of amygdala as well as hippocampus in the AD mice, which may involve in a cause for alteration of behavior phenotype in the AD.
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