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Abstract #3047

In vivo manganese-enhanced MRI of amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Eugene Kim1, Diana Cash1, Camilla Simmons1, Michel Mesquita1, Steve CR Williams1, Clive Ballard2, and Richard Killick3

1Department of Neuroimaging, King's College London, London, United Kingdom, 2The University of Exeter Medical School, Exeter, United Kingdom, 3Department of Old Age Psychiatry, King's College London, London, United Kingdom

Amyloid plaques are a hallmark of Alzheimer’s disease (AD) but are difficult to detect in vivo due to their small size. We investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in the 5xFAD mouse model of AD. Plaque-like hypointensities were present in 3D gradient-echo images in all transgenic mice (n=4) but not wild type littermates (n=4). MP2RAGE T1-mapping (n=2/2) revealed reduced manganese uptake in 5xFAD brains, suggesting neurodegeneration. These results demonstrate the potential for MEMRI to provide biomarkers of AD-related neuropathologies that can be useful for monitoring disease progression and therapeutic response in animal models of AD.

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